- The Portsmouth Brewery, New Hampshire's original brewpub, has been serving great food and outstanding handcrafted beers in a friendly, lively atmosphere since 1991. Please take a few minutes to explore this site. In it, you will find out about our company, our community, and our sister company, the Smuttynose Brewing Company. We are open seven days a week, from 11:30 AM till 12:30 at night. Our ...www.portsmouthbrewery.com