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Tizanidine DESCRIPTION From our sponsors: . From our sponsors: Zanaflex is a centrally acting alpha2-adrenergic agonist. Tizanidine HCl is a white to off-white fine crystalline powder, odorless or with a faint characteristic odor. Tizanidine is slightly soluble in water and methanol; solubility in water decreases as the pH increases. Its chemical name is 5-chloro-4-(2-imidazolin-2-ylamino)-2, ...

Zanaflex is a treatment indicated for the management of increased muscle tone associated with spasticity, a condition affecting the central nervous system ("CNS") causing muscle stiffness and rigidity. Spasticity can occur as a result of many CNS disorders, particularly multiple sclerosis and spinal cord injury.