Alendronate DESCRIPTION NewsLinks Alendronate sodium is an aminobisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Alendronate sodium is chemically described as (4-amino-1- hydroxybutylidene) bisphosphonic acid monosodium salt trihydrate. The empirical ...