Lisinopril and Hydrochlorothiazide DESCRIPTION NewsLinks USE IN PREGNANCY When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ZESTORETIC should be discontinued as soon as possible. (See WARNINGS NewsLinks , Pregnancy, Lisinopril, Fetal/Neonatal Morbidity and Mortality). ZESTORETIC ...