Morning sickness is a problem in 70% of pregnancies, the more severe and dangerous condition known as hyperemesis gravidarum (literally pregnant over-vomiting) occurs in only three pregnancies of every 1000 (0.3%). Most cases happen in the first 8-12 weeks of pregnancy.

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Hyperemesis gravidarum is severe and intractable nausea and vomiting of pregnancy. It may result in weight loss, nutritional deficiencies and abnormalities of fluid, electrolyte and acid-base balance. The peak incidence is at eight to 12 weeks of pregnancy and symptoms usually resolve by week 16.