- Frostbite - Frostbite is a cold-related injury characterized by freezing of tissue. Most cases are encountered in soldiers, in those who work outdoors in the cold, and among winter outdoor enthusiasts. Mountain frostbite is a variation observed among mountain climbers and others exposed to extremely cold temperatures at high altitude. It combines tissue freezing with hypoxia and general body .www.emedicine.com/emerg/topic209.htm