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- Cancer Facts CIS Home Cancer.gov Dictionary Search Date reviewed: 11/19/2001 Cancer Clusters Defining Disease Clusters A disease cluster is the occurrence of a greater than expected number of cases of a particular disease within a group of people, a geographic area, or a period of time. Clusters of various diseases have concerned scientists for centuries. Some recent disease clusters include the ...cis.nci.nih.gov/fact/3_58.htm