Drug monograph about amitriptyline from Internet Mental Health.

Amitriptyline Tables: Pharmacokinetics Bioavailability Peak plasma level Plasma half-life Active metabolites Elimination very variable 30-60% 4 to 8 hours 15 hours (10-28 h)* important* extrarenal *Nortriptyline, the most important metabolite, has a half-life of 36 hours (18-60 hours). It has a polymorphically controlled metabolism (debrisoquine metabolism). In subjects with a slow metabolism ...

Amitriptyline also known as Elavil or Endep, is used as a preventive treatment for Migraine and some types of headaches.

Discussion group for Elavil/amitriptyline patients.