- Welcome to the Frankfort Chamber of Commerce website! Located in Frankfort, Illinois, just 35 miles southwest of Chicago, we are here to help you in anyway with information about our community. Frankfort is located at the intersections of Illinois State Routes 45 and 30. Interstate 80 is just two miles north and Interstate 57 is three miles to the east. The proposed I-355 extension will give ...frankfortchamber.com